ea0056gp34 | Adrenal cortex | ECE2018
Negri Mariarosaria
, Di Gennaro Gilda
, Pivonello Claudia
, Simeoli Chiara
, Vennery Mary Anna
, Barbagallo Federica
, Iacuaniello Davide
, De Martino Maria Cristina
, Isidoro Andrea Maria
, Colao Annamaria
, Pivonello Rosario
Adrenal insufficiency is a rare endocrine disorder characterized by low levels of cortisol associated with increased mortality, also due to inadequate replacement therapy. The replacement with the thrice-daily immediate release hydrocortisone (IRH), in contrast to the once-daily modified-release hydrocortisone (MRH), more appropriately mimicking the physiological circadian rhythm of cortisol (PCRC), is associated with metabolic disorders, mainly due to the non-physiological pe...